The Reina-Valera is a Spanish translation of the Bible, first published in 1569 in Basel, Switzerland, and nicknamed the "Biblia del Oso" (in English: Bible of the Bear). It is also named Biblia del Oso because of the illustracion on the title page of a bear trying to reach a container of honeycombs hanging from a tree.

It was the first complete Bible to be printed, although not the first complete Bible in Spanish; several others, like the 13th-century Alfonsina Bible (translated from Jerome's Vulgate), were published in previous centuries. Its principal translator was Casiodoro de Reina, an independent Lutheran theologian, but a manuscript found at the Bodleian Library gives further evidence of the fact that the Spanish Bible was a community project.