There is a link between insulin resistance and hypertension, type 2 diabetes, dyslipidemia and other metabolic abnormalities that increase an individual’s risk of developing atherosclerotic cardiovascular diseases. This Animation describes this syndrome and the pharmaco therapeutic focus on multiple risk factor intervention using combinations of antihypertensives, low dose aspirin, statins and antihyperglycaemic agents for diabetes as also targeting the underlying insulin resistance.